Common Genetic Variants on Chromosome 9p21 Confers Risk of Ischemic Stroke
نویسندگان
چکیده
منابع مشابه
Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study.
BACKGROUND Epidemiological studies indicate a genetic contribution to ischemic stroke risk, but specific genetic variants remain unknown, with the exception of a few rare variants. Recent genome-wide association studies identified and replicated common genetic variants on chromosome 9p21 to confer risk of coronary heart disease. We examined whether these variants are associated with ischemic st...
متن کاملChromosome 9p21 in ischemic stroke: population structure and meta-analysis.
BACKGROUND AND PURPOSE Sequence variants on chromosome 9p21.3 are implicated in coronary artery disease and myocardial infarction, but studies in ischemic stroke have produced inconsistent results. We investigated whether these conflicting findings were due to false-positive studies confounded by population stratification or false-negative studies that failed to account for effects specific to ...
متن کاملCommon mitochondrial sequence variants in ischemic stroke.
OBJECTIVE Rare mitochondrial mutations cause neurologic disease, including ischemic stroke and MRI white matter changes. We investigated whether common mitochondrial genetic variants influence risk of sporadic ischemic stroke and, in patients with stroke, the volume of white matter hyperintensity (WMHV). METHODS In this multicenter, mitochondrial genome-wide association study (GWAS), 2284 isc...
متن کاملEvaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population
OBJECTIVE Coronary artery disease (CAD), which develops from complex interactions between genetic and enviromental factors, is a leading cause of death worldwide. Based on genome-wide association studies (GWAS), the chromosomal region 9p21 has been identified as the most relevant locus presenting a strong association with CAD in different populations. The aim of the present study was to investi...
متن کاملCommon Variants on Chromosome 9p21 Are Associated with Normal Tension Glaucoma
Although intraocular pressure (IOP) is the most definitive cause of glaucoma, a subtype of open angle glaucoma (OAG) termed normal tension glaucoma (NTG), which occurs in spite of normal IOP, accounts for a large part of glaucoma cases, especially in Japan. To find common genetic variants contributing to NTG in Japanese patients, we conducted a genome-wide association study (GWAS). We performed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2009
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.108.835173